Pharmacological properties Calcitonin Nasal Spray:
a molecule of calcitonin containing 32 amino acid residues in a single polypeptide chain, and the sequence of residues is different in different species. Because salmon calcitonin has a higher affinity to the receptors (as compared with calcitonin mammals, including synthetic human calcitonin), its clinical effect is more like the strength and duration. Calcitonin – one of the main factors regulating mineral metabolism in bone tissue. In action on bone is an antagonist of parathyroid hormone, calcitonin, with effects on both bone and on calcium homeostasis. Significantly reduces the yield of calcium from bone in conditions with increased speed of resorption such as osteoporosis, Paget’s disease, cancer osteolysis. Increases the formation and increases the activity of osteoblasts. Inhibits osteolysis, which causes reduction of pathologically elevated levels of serum calcium. In addition, increases the excretion of calcium, phosphorus, and sodium excretion by reducing their reabsorption in the renal tubule. The concentration of serum calcium is not reduced below normal. The drug has analgesic effects (especially pain in the bones), due to the action on the CNS.
The bioavailability of nasal calcitonin in the application is 3-6% compared to 70% bioavailability when administered parenterally. Calcitonin is rapidly absorbed nasal mucosa, and its maximum plasma concentration achieved during the first hour. The half-life of plasma – 16-43 min. Cumulation after repeated administration did not say. When used in doses higher than recommended, the drug concentration in plasma is higher, but the relative bioavailability is not increased.
Indications: postmenopausal osteoporosis, bone pain associated with osteolysis and / or osteopenia, bone Paget’s disease (osteitis deformans) neurodystrophic disease (algodistrofiya and Zudeka disease) caused by various factors, such as post-traumatic painful osteoporosis, reflex dystrophy syndrome “shoulder -brush “causalgia, medical neurotrophic disorders.
APPLICATION Calcitonin Nasal Spray:
intranasal. For the treatment of osteoporosis The recommended dose is 200 MO / day (one injection). In order to prevent progressive bone loss at the same time with the use of calcitonin-Ratiofarm recommended the appointment of calcium and vitamin D in adequate doses. The treatment duration is at least 3 months. If necessary, treatment can be extended.
When bone pain associated with osteolysis and / or osteopenia, the daily dose is 200 MO with a single dose. Higher doses should be distributed in several stages. Dose should be adjusted to suit the individual needs of the patient. To achieve full analgesic effect may take several days. In the long-term therapy the initial dose is reduced and / or increase the interval between doses. When Paget’s disease drug administered daily at a daily dose of 200 MO. In some cases, early treatment may need to use doses of 400 MO / day, which can be divided into 2 doses.
When neurodystrophic diseases prescribed 200 MO / day (one dose) daily for 2-4 weeks. Perhaps the appointment of 200 additional Defense next day to 6 weeks depending on the dynamics of the patient.
CONTRAINDICATIONS Calcitonin Nasal Spray:
Hypersensitivity to synthetic salmon calcitonin and / or other component of the drug.
SIDE EFFECTS Calcitonin Nasal Spray:
The most common side effects – nausea, vomiting, dizziness, flushing, accompanied by a feeling of heat, arthralgia. In a few cases – polyuria, and chills. These effects disappear on their own, and only occasionally need to temporarily reduce the dose.
In rare cases, calcitonin-Ratiofarm can cause the development of hypersensitivity reactions – both local and generalized cutaneous reactions as skin rashes. In some cases, may mark the AH and / or peripheral edema. Other local adverse reactions noted rhinitis, dryness of nasal mucosa, epistaxis or sinusitis.
Precautions Calcitonin Nasal Spray:
Prolonged use may form antibodies to calcitonin, but clinical efficacy is not affected.
Patients with chronic rhinitis, nasal spray applying, in need of constant medical supervision, since the resorption of the active substance from the inflamed mucous membranes of the nose is raised.
Because salmon calcitonin is a peptide, there is the likelihood of systemic allergic reactions. There are reports of anaphylactoid reactions and sporadic type of anaphylactic shock. If you suspect a sensitivity to salmon calcitonin prior to treatment to a skin test using diluted sterile Valium calcitonin.
Children. No information on the use of calcitonin nasal spray-Ratiofarm children.
Pregnancy and breast-feeding is not recommended (because of the lack of reliable information).
Effects on ability to drive vehicles or by other mechanisms: the use of the drug may cause dizziness, which must be considered in this work.
INTERACTION Calcitonin Nasal Spray:
not known.
OVERDOSE Calcitonin Nasal Spray:
Symptoms include nausea, vomiting, dizziness and flushing. The drug is discontinued and to supportive and symptomatic treatment.
